Association of CK-19 with histopathological grading of oral squamous cell carcinomas (OSCC).

Abstract

Objectives: To correlate CK-19 with different histopathological gradings of oral squamous cell carcinomas (OSCCs). Methods: Study Design: Descriptive study. Setting: Department of Outpatient, ISRA Dental College Hospital. Period: January 2014 to November 2019. Material & Methods: In current study 60 suspected patients of oral squamous cell carcinomas were enrolled for cancer diagnosis and histopathological evaluation. Incisional biopsy method was opted for tissue sample collection. Patients from both genders were tested for CK-19 at different histopathological gradings. Ethical approval was properly taken from Institutional review board and patients’ willingness to participate in the study was ensured. For statistical data analysis SPSS version 21.0 and Revman5.30 multiple tools were used. Results: Histopathological grading of sixty suspected cases of OSCCs was done into four different gradings which include, poorly differentiated, moderately differentiated, well differentiated and undifferentiated OSCCs. Fifty-two (87 %) of the included subjects were male, where only 8 patients were female. The mean age of female to male was (36.14 vs. 43.21 years).  Out of 12 positive cases of OSCCs. CK-19 was found positive in 10 cases (83.3%) in well differentiated Oral Squamous cell carcinomas, where only 2 cases (16 %) of moderately differentiated OSCCs were positive against CK-19. Conclusion: Our outcomes suggest CK-19 has strong association with well differentiated and moderately differentiated Oral Squamous cell carcinomas. We highly recommend further research standardizing CK-19 as a promising histopathological grading marker.