HEPATITIS B VIRUS

Authors

  • JIANBO XIAO College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China
  • Lei Zhang Central South University, Changsha 410083, China.
  • XIAOQING CHEN College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China
  • Ming Xu * Central South University, Changsha 410083, China.
  • XINYU JIANG Central South University, Changsha 410083, PR China

DOI:

https://doi.org/10.29309/TPMJ/2007.14.02.4883

Keywords:

Marchantia Convoluta, Flavonoids, Anti- HBV

Abstract

Dried leaves of Marchantia convoluta are largely used to protect livers,
and to treat tumefaction of skins in China. Flavonoids from Marchantia Convoluta (MCF) was one of the most
potentially effective anti-inflammatory. MCF was studied here for its ability to inhibit the proliferation of 2,2,15 cells
(clone cells derived from HepG2 cells that were transected with a plasmid containing HBV, DNA). All concentrations
(5,10,20 and 40 :g/ml) of MCF inhibit hepatitis B surface antigen (HbsAg) and hepatitis B E antigen (HbeAg) in the
cultured medium released from 2.2.15 cells. Analysis of morphological changes of MCF-treated phase- contrast
microscope revealed a possible model of action for MCF to inhibit Proliferation of 2.2.15 cells by inducing apoptosis.

Author Biographies

Lei Zhang, Central South University, Changsha 410083, China.

Research Institute for Molecular Pharmacology
and Therapeutics

Ming Xu *, Central South University, Changsha 410083, China.

Research institute of Molecular Pharmacology and
Therapeutics

XINYU JIANG, Central South University, Changsha 410083, PR China

College of Chemistry and Chemical Engineering,

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Published

2007-09-06

Issue

Vol. 14 No. 02 (2007): Vol 14 No.02

Section

Articles