Obesity a multifactorial medical problem, presentation to treatment: A Systematic Review.


  • Ehsan Humayun Hazara University, Mansehra, Pakistan.
  • Uroba Ali Islamic International University, Islamabad, Pakistan
  • Nodia Shujaat Hazara University, Mansehra, Pakistan.




Adipogenesis, BMI, Genes, Genetics, Obesity


Objective: The aim of the current article is to critically review the current literature on the presentation and treatment of obesity as it is one of the major health concerns, that can affect the metabolism of an individual by causing some of the most serious and devastating medical complications. Results: It affects the quality of normal human body function. During the process of aging, it causes weakness in overweight and obese individuals. Environment, diet, genetics, maternal factors are some of the major causes involved in the progression of obesity. A number of genes involved in metabolism, adipogenesis, and lipolysis have a proven role in weight gain. Obesity is associated with various diseases such as type II diabetes, cardiovascular disorder, metabolic abnormalities, cancer, cataract, and Urinary Incontinence, etc. Treatment of obesity is important, but treatments under consideration are controversial as obesity causes health risks related to the increased body mass and weight loss in the older population. Conclusion: Moreover, the therapies involved in weight loss have to keep an eye on the side effects of instant weight loss for the human body.

Author Biographies

Ehsan Humayun, Hazara University, Mansehra, Pakistan.

MS (Biochemistry and Molecular Biology)

Lecturer Biochemistry

Uroba Ali, Islamic International University, Islamabad, Pakistan

MS Biotechnology

Biological Sciences

Nodia Shujaat, Hazara University, Mansehra, Pakistan.

M.Phil (Biochemistry)

Assistant Professor Biochemistry