Positive predictive value of BIRADS (Breast imaging reporting and data system) IV lesions in detection of carcinoma breast, using histopathology as a gold standard.

Abstract

Objective: To determine the Positive Predictive Value of BIRADS IV lesions in detection of carcinoma breast, using histopathology as a gold standard. Study Design: A Cross-Sectional study. Setting: Department of Radiology Allied Hospital Faisalabad. Period: From 01-09-2015 to 01-03-2016. Material & Methods: 93 female patients referred to radiology department were included after taking consent. Data were collected on structured proforma. The final diagnosis of the BIRASDS IV lesion seen on mammography has made by consultant. Then patients were sent for biopsy. Mammographic diagnose was then compared with the histopathological diagnose by consultant. The primary performance outcomes of diagnostic mammography like sensitivity, specificity and accuracy were evaluated. Results: The mean age of patients was 45.96±7.85years. There were 19 females had subcategory A, 22 had subcategory B and 52 females had subcategory C. The mean size of lump was 3.23±0.69cm. The mean duration of symptoms was 3.97±3.43months. On BIRADS IV, malignant lesion detected in 71 (76.3%) females while 22 (23.7%) females had benign lesion. On histopathology, malignant lesions detected in 50 (53.8%) females while 43 (46.2%) females had benign lesion. Findings of BIRADS IV were compared with histopathology and the PPV was 43.7% and NPV was 13.6%. Conclusion: Through findings of this study, we concluded that in comparison to histopathology, BIRADS IV had PPV of 43.7% and NPV of 13.6%. In some cases, we can rely on BIRADS-IV and skip interventional method including biopsy for diagnosis of breast lesion.