In-hospital mortality in patients with NON-ST segment elevation myocardial infarction in relation to high risk global registry of acute cardiac events score.

Abstract

Objectives: Presage for early risk stratification is consequential for long term clinical outcomes in patients with non-ST elevation acute coronary syndrome. Thrombolysis in Myocardial Infarction risk scores (TIMI) and Global Registry of Acute Cardiac Events (GRACE) have been most extensively investigated risk scores till date for risk stratification in patients admitted with Cardiovascular disease. Study Design: Descriptive Case Series. Setting: Department of Cardiology Ayub Teaching Hospital, Abbottabad. Period: 4th August 2016 to 4th April 2017. Material & Methods: 199 patients diagnosed with NSTEMI were included in the study after obtaining an apprised consent. Risk stratification of each patient was done according to GRACE score. Patients were followed up during their hospital stay and their outcome was recorded on a pre-designed pro forma. The outcome was described as either death or discharge. Results: Mean±SD GRACE score was 156.12±20.65. The overall mortality in the study population was 11.6% (n=23). When the outcome variable was stratified according to age, gender, diabetes mellitus, obesity and hypertension, results were found in case of hypertension (p< 0.05), and statistically no significant in the case of other variables. Conclusion: A high risk GRACE score is associated with increased in-hospital mortality in patients with NSTEMI.