Positive predictive value (PPV) of computed tomography in diagnosing wilms’ tumor using histopathology as gold standard.

Abstract

CT can also accurately identify vascular invasion that will impact surgical approach along with identification of the preoperative parameters associated with increased risk of intraoperative Wilms’ tumor spill. Objectives: To determine positive predictive value of CT scan in diagnosing wilm’s tumour, taking histopathology as gold standard. Study Design: Descriptive, cross sectional study. Setting: Department of Urology & Renal Transplantation Centre, Bahawal Vitoria Hospital, Bahawalpur. Period: From July 2017 to June 2018. Materials & Methods: A total of 81 patients with suspected wilm’s tumour on ultrasonography of age 1-12 years of either gender were included. Patients with recurrent tumour and undergoing pre-op chemotherapy were excluded. All the patients were then underwent CT scan and looked for presence or absence of wilm’s tumour. The results were compared with histopathology. Results: Mean age was 5.23 ± 3.28 years. Majority of the patients 56 (69.14%) were between 1 to 6 years of age. Out of these 81 patients, 61 (75.31%) were female and 20 (24.69%) were males with female to male ratio of 2.9:1. CT scan supported the diagnosis of wilm’s tumour in all 46 patients. Histopathology confirmed wilm’s tumour in 41 (true positive) cases where as 05 (False Positive) had no wilm’s tumour on histopathology. Positive predictive value of CT scan in diagnosing wilm’s tumour, taking histopathology as gold standard was 89.13%. Conclusion: This study concluded that positive predictive value of CT scan in diagnosing wilm’s tumour is quite high.