Human papilloma virus prevalence and its correlation with clinical presentation and histological grading in oral squamous cell carcinoma.

Abstract

Objectives: The objectives of this study were to determine the prevalence of Human Papilloma virus 16 in patients with oral squamous cell carcinoma presenting at Isra University Hospital and to correlate the existence of Human Papilloma virus 16 in squamous cell carcinoma with clinical presentation, habits and histological grading. Study Design: Interventional Study. Setting: Department of Oral Surgery, Isra Dental College Hospital. Period: July 2017 to December 2017. Material & Methods: A sample of 60 patients presenting were selected by non-probability purposive sampling. Patients reporting to Isra Dental College, Oral Surgery OPD Isra University during the study period with clinical suspicion of Oral Squamous Cell Carcinoma were included. Results: Age category was from 20 till 60+ years of age whereas age group of 40-49 (36.7%) was the most frequent age in the study population followed by 30-39 (30%) years and 50-59 (23.3%) years of age respectively. The mean and standard deviation was 43.35 ± 10.156 respectively. Maximum numbers of people were seen to have more than one habit i.e. they were using guthka with smoking or areca nut with guthka and smoking etc. areca nut, cigarette smoking and guthka were among the others most used. The mean was 6.32 with standard deviation of 2.954. Most of the patients had submucous fibrosis on the right side of buccal vestibule 24 (40%) and 22 (36.7%) had submucous fibrosis on the left side of buccal vestibule. 56 (93.3%) of the patients had well differentiated squamous cell carcinoma whereas 4 (6.7%) has moderately differentiated squamous cell carcinoma. No patients were seen to have poorly differentiated squamous cell carcinoma. Conclusion: In conclusion, the Prevalence of HPV 16 in our study was found to be 11.7%. There was no association between habits and histological grading with Human Papillomavirus 16 in patient with oral squamous cell carcinoma. But there was association between HPV16 and clinical presentation of OSCC because of p-value (.015) which was significant.