Noninvasive Ventilation in patients with Sleep Apnea syndrome complicated with GERD.

Abstract

Objectives: The access the clinical effects of non-invasive ventilation in patients with obstructive sleep apnea (OSA) accompanied with GERD. Study Design: Randomized Controlled Trial. Setting: DHQ Teaching Hospital Faisalabad Material. Periods: January 2018 to December 2018. Material & Methods: As Stated in sleep study results, 100 patients with OSA were divided into three different groups according to the disease severity that is mild, moderate, and severe groups. Gastroscopy was performed in all the patients and underwent GERD assessment. Twenty-three patients with OSA accompanied with GERD were segregated into an experimental group and control group, who were given omeprazole (40 mg/time per day) combined with non-invasive ventilation therapy and omeprazole (40 mg/time per day) alone, respectively, for eight weeks. After that, they Underwent gastroscopy and GERD assessment. Results: Among all the 100 patients with OSA, 48 were in the mild group, 33 in the moderate group, and 19 in the severe group. Their GERD scores were 8.26 ± 1.11, 9.87 ± 1.79, and 12.34 ± 2.02, respectively, with a statistical difference (P = 0.004). Out of 23 patients with OSA associated with GERD were divided into The Experimental Group, which included 12 patients, and Control Group, which included. 11 patients. The gastroscopy efficacy rates for inflammation management were 86.53% and 53.09%, respectively, with a statistical difference (P = 0.011). The ΔGERD scores for the two groups also differed significantly (5.11 ± 1.54 vs 2.35 ± 0.72, P = 0.034). Conclusion: Patients having severe OSA were associated with a high incidence rate of GERD than those with moderate or mild OSA. Those who were treated with non-invasive ventilation combined with PPI shown much better results than PPI alone in respect of clinical effects in patients with OSA associated with GERD.