Significance of Vitamin D3 in allergic reactions and IgE levels in asthmic patients.

Abstract

Objectives: When a person is exposed to the sun, vitamin D3 is a nutrient produced by the body. Unless we don’t get enough sunlight, we can't get enough vitamin D3. In the case of asthma, the respiratory tract expands due to mucus because they become inflamed. Inflammation is the body's reaction to injury, infection or irritation. Researchers are interested in vitamin D3 because it can decrease inflammation, theoretically it can make the airway recovered. The study aims to analyze the significance of Cholecalciferol (Vitamin D3) in asthmatic cases. Study Design: Comparative study. Setting: Baqai Medical University’s allied Hospitals. Period: From July 2014 to April 2015. Material & Methods: The study included diagnosed asthmatic individuals. IgE and Vitamin D₃ levels were performed by ELISA kit method. Result: A comparative study was performed between the 50 healthy subjects and 50 Asthmatic patients. Mean ± SD was calculated for Vitamin D3 level and IgE of cases (asthmatic patients) and control (healthy subjects). It was found that vitamin D3 level was significantly low in asthmatic patients (11.53 ± 4.11) as compared to healthy subjects (25.32 ± 4.79),with statically significant difference as shown by the p-value <0.01. Correspondingly mean value of IgE value was higher in asthmatic cases (4.01 ± 0.65) in our study in comparison with healthy subjects (3.12 ± 0.43) with statically significant difference (p-value < 0.01). Conclusion: The present study signifies Vitamin D₃functions in immune system and inflammatory reactions. Vitamin D enhances immune cells function thereby reduces inflammatory responses. Immunoglobulin E level in serum was higher in asthmatics as compared to normal subjects.