Serum ferritin and iron profile in helicobacter pylori infected young adult male reporting at a tertiary care hospital

Abstract

Objectives: Determination of serum ferritin and iron profile in Helicobacter pylori infected young adult male reporting at a tertiary care hospital of Sindh. Study Design: Case control study. Study Setting & Duration: Department of Medicine, Layari General Hospital Shaheed Muhtrama Benazir Bhutto Medical College from January 2015 to February 2016. Study Subjects and Methods: 100 cases (H. pylori stool specific antigen positive) and 100 controls (H pylori negative) were selected and studied. 5 ml blood was collected in a disposable syringe by venesection. 2 ml was put in EDTA tubes and 3 ml was centrifuged (3000 x rpm for 10 minutes). Sera were used for the estimation of iron profile. Elisa assay method (Fortress diagnostics) detected the H. pylori stool specific antigen (HpSA). Data was analyzed on SPSS 22.0 (USA) at 95% CI (P≤ 0.05). Results: Age of control and cases was noted 35.48±4.79 and 33.60±3.96 years (P=0.053). Hb, Hct and RBC counts were low in cases (P=0.0001) significantly. Serum iron (Fe++), ferritin and TIBC in controls and cases were noted 152.72±6.08 and 118.79±43.30 μg/dl, 394.34±136.50 and 529.87±101.0 ng/dl, & 140.80±19.99 and 130.88±28.46 μg/dl respectively (P=0.0001) (Table-I). Conclusion: Helicobacter pylori infection causes iron malabsorption as detected by serum iron and ferritin and total iron binding capacity in young adult male.