Pattern of bacterial isolates causing neonatal septicemia along with their pattern of antibiotic susceptibility.

Abstract

Objectives: We planned this study to observe the pattern related to bacterial isolates causing neonatal septicemia along with their pattern of antibiotic susceptibility. Study Design: Prospective study. Setting: Department of Neonatology, Sheikh Khalifa Bin Zaid Al Nahyan Teaching Hospital, Rawlakot. Period: From 1^st January 2018 to 30^th June 2018. Material & Methods: Prior to empiric antibiotic usage, blood was collected from neonates having clinical sepsis and sent for blood culture. A total of 60 neonates with culture proven sepsis were enrolled for this study. Reports of blood culture were evaluated for isolates of bacteria as well as patterns of sensitivity for frequently used antibiotics in the institution. SPSS version 21.0 was used for data entry and analysis. Results: A total of 60 neonates having culture proven sepsis were enrolled in the current study. Amongst these, 39 (65.0) were male and 21 (35.0%) female. Early onset of sepsis was diagnosed in most, 42 (70.0%) neonates. Majority of neonates, 50 (83.3%) were delivered in the same hospital. Gram negative isolates were found in 43 (71.7%) and 15 (25.0%) gram positive while 2 (3.3%) candida spp. In terms of pattern of antibiotic sensitivity, 4 (9.3%) isolates of gram negative were found resistant to every antibiotic routinely used while gram positive isolates showed excellent sensitivity to vancomycin. Conclusion: Gram negative isolates of organisms were found to be the most sensitive to carbepenems (especially meropenem) as well as aminoglycosides while gram positive isolates showed excellent sensitive regarding vancomycin.