ASTHMATIC PREGNANT FEMALES
EXPRESSION OF MATRIX METALLOPROTEINASES (MMPs)
DOI:
https://doi.org/10.29309/TPMJ/2018.25.04.351Keywords:
Matrixmetaloproteinases (MMPs), Tumor Necrosis Factor-alpha (TNF-α), 4-hydroxynonenal (4-HNE), 8-hydroxy-2-deoxyguanosine (8OHdG)Abstract
Objectives: To evaluate the expression of MMPs and oxidative stress markers in
pregnant Asthmatic females. Period: July 2015 to Dec 2015. Design: Cross sectional. Setting:
Jinnah Hospital Lahore. Background: Maternal asthma throughout pregnancy unfavorably
alters pregnancy outcomes but evaluation of the causes, and the ability to assess interventions,
is restricted having inadequate knowledge of complex interactions between underlying
inflammation, oxidativestress and structural changes in asthmatic airways. Methods: Total 100
patients were included in study. Fifty ascontrols. Clinically diagnosed asthmatic pregnant females
coming to GyneaUnit of Jinnah hospital were included.Females on any medication or suffering
from any congenital disease were excluded out of the current study. Matrix metalloproteinase’s,
TNF-α, 8OHdG, 4-HNE and Isoprostanes are measured by ELISA. Results: Results shows that
MMP- 7 and MMP-9 have positive correlation with proinflammatory cytokine TNF-α but MMP-
8 have significantly positive correlation with it (TNF-α Vs. MMP-8 r=0.946. On the other hand
MMP-7 has significant correlation besides other MMPS (MMP-7 Vs.8OHdG r=0.719) indicating
a positive correlation between proteinases and marker of DNA damage indicating epithelial
shedding in case of Asthma. Conclusion: The sole objective of effective asthma management
in pregnancy is to prevent exacerbations. Antioxidants should be added in diet so to ovoid
oxidative stress caused to airway epithelial and structural cells and MMP inhibitors may be used
as therapeutic agents as well as measuring MMP levels as diagnostic or prognostic markers.
