ACUTE PANCREATITIS;

A COMPARATIVE STUDY TO ASSESS THE CLINICAL OUTCOME OF ACUTE PANCREATITIS IN RELATION WITH MAJOR ETIOLOGIES.

Abstract

Objectives: To determine the clinical outcome of acute pancreatitis in relation with major etiologies (Gallstones, Alcohol, and Drugs). Study Design: Cross sectional hospital based study. Setting: Aga Khan University Hospital. Period: 16 years (from 1^st January 2001 to 30^th June 2016). Methods: All patients with acute pancreatitis admitted. Major risk factors of pancreatitis such as gallstones, alcohol, and drugs were evaluated and outcomes assessed for the development of complications and mortality. Results: We evaluated 3049 patients with acute pancreatitis, the causative agents found, 80.35% (N = 2450), followed by Alcohol 13.05% (N = 398) and drugs 6.59% (N = 201), respectively. Patients with alcohol abuse were relatively older 53.74 years compared to patients with gallstones 39.54 years and drugs induced 43.26 years AP. Among them, the overall complication rate was 5.05% (N = 155). The most common complication was development of sepsis 45.8% (N = 71) and the overall mortality rate observed was 0.91% (N = 28). Conclusions: Gall stones are the leading cause of acute pancreatitis while drugs are the rare cause, however in significant number of patients cause remained obscure. Based on the above results patients with drug induced pancreatitis have good outcome as compared to gall stones and alcohol induced acute pancreatitis, however further studies warranted.