TYPE II DIABETES MELLITUS;

FREQUENCY OF ASYMPTOMATIC ELEVATION OF LIVER FUNCTION ENZYMES IN TYPE II DIABETES MELLITUS PATIENTS USING STATINS.

Abstract

Objectives: To determine the frequency of asymptomatic elevation of liver function enzymes in type II diabetes mellitus patients using statins. Study Design: Cross sectional study. Setting and Period: Nishtar Hospital Multan, from February 2017 to February 2018. Material and Methods: A total of 335 patients were enrolled for this study. Sample size was calculated from the reference study.⁹ Clinical and biographical data was obtained from each patient in the form of previous medical records and patient interview such as, sex, age, height, weight, age at onset of diabetes, family history of diabetes, duration of diabetes, family history of liver diseases, medication history. All the data was measured and recorded by the researcher himself. Data thus obtained was subjected to statistical analysis by using computer software SPSS version 23. Mean and standard deviation was calculated for continuous variables while frequency and percentage was calculated for categorical variables. A p value of less than or equal to 0.05 was taken as significant for univariate test. ANOVA test was utilized to evaluate the relationship ALT and AST and other metabolic parameters. Results: Although the prevalence of elevated ALT increased with the increasing age, duration of diabetes, BMI, FBS and TG, but it was not statistically significant with (p=0.634), (p=0.759), (p=0.844), (p=0.400) and (p=0.246) respectively. Similarly, the prevalence of elevated AST increased with the increasing age, duration of diabetes, BMI, FBS and TG, but it was not statistically significant with (p=0.779), (p=0.945), (p=0.987), (p=0.199) and (p=0.933) respectively. (Table II). Conclusion: From this study it can be concluded that use of statins does not alter the usual finding of elevated liver enzymes among the patients with type two diabetes mellitus.