Hyperuricemia in Systemic Hypertension and its correlation with systolic and diastolic blood pressure.

Abstract

Objectives: To determine the serum uric acid (SUA) in systemic hypertension and its correlation with systolic (SBP) and diastolic blood pressure (DBP). Study Design: Cross sectional study design. Setting: Department of Medicine, Isra University Hospital. Period: From April 2016 – February 2017. Material and Methods: A sample of 100 cases of systemic hypertension and 100 age, gender, body weight and BMI controls were selected through non-probability purposive sampling. Volunteers were asked for history, physical examination, and blood sampling. Systemic BP was measured with a mercury sphygmomanometer. 2 ml venous blood was taken, centrifuged and sera were used for detection of SUA. Data was saved in a pre- structured Performa. Computed based statistical software (SPSS v 22.0, IBM, Incorporation, USA) was used for data analysis. Data variables were analyzed at 95% CI (P ≤ 0.05). Results: Serum uric acid in controls was 2.91±0.75 mg/dl compared to 5.70±1.76 mg/dl (P=0.0001). 57% of cases revealed hyperuricemia compared to 11% in control (X²=17.5, P=0.0001). Serum Uric acid showed significantly positive correlation with Systolic BP (r= 0.518*, p=0.0001) and Diastolic BP (r= 0.397**, p=0.0001). Conclusion: The present study reports hyperuricemia in 57% cases of systemic hypertension and uric acid shows positive correlation with systolic and diastolic blood pressure.