COAGULASE NEGATIVE STAPHYLOCOCCUS SPECIES

RESISTANCE AND THERAPEUTIC DECISIONS AT THE TURN OF THE NOVEL MILLENNIUM

Abstract

Objective: Department and sample wise distribution along with drug-resistant
pattern and best therapeutic choice of drugs against Coagulase-negative Staphylococcus
species (CoNS). Study Design: Cross-sectional study. Setting: Department of Microbiology
AIMC Lahore Pakistan. Period: 1st January 2016 to 25th May 2017. Methodology: About
4597 samples were collected from various departments and processed for antimicrobial
resistant testing. Results: Of 4597 samples, culture positive were 40.4% CoNS were 9.0%
and 22.3% of total and total culture positive specimens respectively The highest rate isolation
rate of CONS was found in ICU 32.4%, Sample-wise 34.1% in blood samples.0% resistant
to Linezolid, Teicoplanin, and Vancomycin, while very high resistant rate against penicillin
77.8%, Cotrimoxazole 60%, Methicillin 59.8%,Co-amoxiclav 54%,Clindamycin 48.7%,Fusidic
Acid 463%, Doxycycline 45.1%, Erythromycin 44.9%, Amikacin 42%, Ciprofloxacin 41.8% and
Gentamycin 23%. Conclusion: Linezolid, Vancomycin, and Teicoplanin are the best choice of
drugs while emergence of drug-resistant to other basic drugs is alarming