PHARMACOKINETICS FOR DOSE PROPORTION

ESTIMATION OF 250 MG CEFACLOR TABLET IN MALE VOLUNTEERS

Abstract

Objective: To estimate dose proportion for male volunteers by calculating pharmacokinetics following oral administration of Cefaclor (CCL) 250mg Tablet and to check the relative susceptibility of four bacterial strains Design: Randomized Clinical Trial, case series. Setting: Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad. Period: From Mar 2006 to Feb 2007. Materials and methods: Blood samples were collected for the period of 12 hours in heparinized tubes. Collected samples were centrifuged at 3000xg and
plasma thus separated was stored at -10̊C until further analysis. The CCL plasma concentration was determined via bioassay using disc diffusion method. Pharmacokinetics parameters were calculated using American Pharmacology Organization (APO) computer software. Results and conclusion: Renal Clearance (CL), Volume of distribution (VD), Time of Peak (T ), Maximum plasma concentration (C ), max max
Mean Residence Time (MRT), Absorption half life, Elimination half life & the Area Under plasma Concentration (AUC ) showed that the four t0 to t12h bacterial strains have different susceptibility against cefaclor and administration of cefaclor at rate of 250 mg as tablet orally thrice daily maintained considerable concentration (>MIC) that prove it to be very effective for the treatment of specific infections in male volunteers.