Analysis of effects of acid suppression therapy on renal tissue using experimental animal.

Abstract

Objectives: To analyze the effects of acid suppression therapy by proton pump inhibitors on renal tissue by using mice as experimental animal. Study Design: Randomized control trial. Setting: Animal house of University of Sargodha. Period: 6 weeks (From 1^st January 2018 to 15^th February 2018). Material and Methods: The sample consisted of 60 mice. Simple Random Sampling was the technique which was used for the sampling procedure. The mice were procured from Veterinary University Lahore Punjab. The animals were handled according to the international standards of environmental and ethical conditions. The animals were divided into three groups. One group was labeled as control group for comparison and the other groups served as experimental. The histological study was done to analyze the effects of proton pump inhibitors. Results: Histological analysis of the sections made from the renal tissue revealed that acid suppression therapy given in the form of proton pump inhibitors induced toxic effects on the kidneys. The glomerulus was observed to be congested along with cellular infiltrate in the interstitium.