SIALIC ACID AS A PREDICTOR OF TYPE 2 DIABETES MELLITUS
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DOI:
https://doi.org/10.29309/TPMJ/2008.15.02.2811Keywords:
GDM, gestational diabetesmellitus, OGTT, oral glucose tolerance test, TSA, total sialic acid, WHO, World Health Organization.Abstract
Inflammatory markers predict type 2 diabetes. Gestational Diabetes Mellitus
(GDM) predicts type 2 diabetes. Objective: To examine the association of inflammatory markers with GDM, we
investigated total sialic acid (TSA) in women with and without previous GDM.Design & methods:All women with GDM
and a random sample of women from diabetic center of SirGanga Ram Hospital, Lahore were taken after an interview,
an oral glucose tolerance test and anthropometry were performed. A total of 46 women with and 50 women without
previous GDM completed the protocol. Results: Mean TSA was significantly higher in women with (71.8±11.1 mg/dl)
than without (67.5±9.8 mg/dl) previous GDM (P< 0.05). In a linear regression model, TSA was 4 mg/dl (P< 0.05) higher
in women with previous GDM, after adjustment for BMI and fasting insulin sensitivity. In a similar model, current 2-h
plasma glucose levels were associated with higher TSA levels after adjustment for waist-to-hip ratio and the log of
triglycerides. TSA was strongly correlated with individual components and aggregates (r = 0.55, P< 0.001) of the
metabolic syndrome. Conclusions: Increased TSA levels are associated with previous GDM and are strongly linked
to the metabolic syndrome. These findings in young women suggest that a chronic mild systemic inflammatory response
is an early feature of the metabolic syndrome and that GDM may be a window for its investigation.
