GLOMERULOSCLEROSIS

LIPIDS AND LIPOPROTEINS, A RISK FACTOR

Abstract

Objective: Objective is to determine the changes in lipids and lipoproteins in patients with glomerulosclerosis and healthy controls.
Place and Duration: Department of Biochemistry, Frontier Medical College, Abbottabad with the collaboration of Nephrology Unit, Ayoub
Medical Complex, Abbottabad. April, 2006 February 2007. Material and Methods: Study includes 50 subjects out of which 25 adult patients
(18 males, 7 females; age range 20-50 years) with glomerulosclerosis were selected from Nephrology Unit of Ayoub Medical Complex,
Abbottabad. Apparently, 25 clinically healthy volunteers of similar age, sex, body mass index (BMI), and socio-economic status as that of
patients, were selected from various areas of Abbottabad, as controls. Serum triacylglycerols, serum total cholesterol, and HDL-cholesterol
levels were measured by kit method. LDL-cholesterol was calculated according to the Friedewald formula17. Serum VLDL-cholesterol as
calculated according to the formula proposed by Wilson cited by Delongi18 The results were expressed as mean ± standard error of mean.
Statistical analysis was done using student's test. Results: Distribution of 25 patients and 25 controls, according to age is made. Male subjects
with glomerulosclerosis were greater in number than female, with male to female ratio of 1.85:1. Comparison of serum TGs, TC, HDL-c, LDL-c,
VLDL-c, and HDL-c, LDL-c ratio. The mean values of TAGs, TC, HDL-c, LDL-c, VLDL-c, and ratio of HDL-c, vs. LDL-c of patients were observed
significantly high (P<0.001), when compared to controls. In addition significant low values (P<0.001) of HDL-c in patients were also observed
when compared to healthy controls. Conclusion: It is concluded that the results of this study provide evidence for raised lipids and lipoproteins
levels, which is invariable feature of nephritic syndrome with glomerulosclerosis. It is suggested that the patients with nephritic
glomerulosclerosis should be assessed and managed to avoid potential of accelerating the development of coronary artery disease and
increasing risk of renal failure. Hopefully earlier intervention might decrease higher morbidity and mortality.