DYSLIPIDEMIA;

HELICOBACTER PYLORI INFECTED PATIENTS

Abstract

Objective: To determine the frequency of dyslipidemia in Helicobacter pylori
infected patients. Patients and methods: This cross sectional descriptive study of six months
study was conducted at Liaquat University Hospital Hyderabad from 01-03-2012 to 31-08-
2012. All the patients between 19 to 60 years of age present with symptoms of dyspepsia,
bloating or epigastric discomfort for more than 01 week duration were admitted and evaluated
for Helicobacter pylori infection. Thereafter the positive cases (Helicobacter pylori infected
patients) were further evaluated for dyslipidemia. Results: During six month study period,
total 144 patients (95 males and 49 females) with Helicobacter pylori infection were evaluated
for dyslipidemia (lipid profile). Majority of patients were from urban areas 110/144 (76%).
The mean ±SD for age of patients with Helicobacter pylori infection was 35.94±10.77. The
mean age ±SD of dyslipidemic patient was 32.62±6.52. The dyslipidemia was identified in 87
(60.4%) patients, of which 51(58.6%) were males and 36(41.4%) were females. Regarding the
pattern of dyslipidemia, ten (11.4%) patients had raised serum triglycerides level, twenty eight
(32%) had raised LDL-C level, twenty six (28.9%) had raised serum cholesterol level, seven
(8.7%) had low HDL-C level and sixteen (18.3%) had mixed dyslipidemia. The mean ±SD of
hypertriglyceridemia, ↑HDL-C, ↑LDL-C and hypercholesterolemia in dyslipidemic Helicobacter
pylori infected was 280.72±22.85, 24.21±2.63, 180.63±12.98 and 285.21±23.63 respectively.
Conclusions: The H. pylori infected patients are prone to acquire dyslipidemia, therefore the
present study observed 60.4% prevalence of dyslipidemia with male predominance (58.6%)