HYPERINSULINEMIA AND ITS ASSOCIATION WITH POLY CYSTIC OVARIAN SYNDROME

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Abstract

Objective: To determine the variable clinical presentation of Poly cystic ovarian
Syndrome (PCOS) & its association with Hyperinsulinaemia in young adolescent girls. Patients
& Methods: A descriptive study was conducted for one year from February 2009-2010 at Isra
University Hospital Hyderabad (IUH). 136 adolescent girls who came in OPD with suspected
features of polycystic ovarian syndrome were recruited. Biochemical test, ultrasound of pelvis
and test to determine hyperinsulinemia were done .woman having preexisting ovarian pathology
were excluded. All results were analyzed on statistical software SPSS version 16. Frequencies
and percentages were calculated. Result: Insulin resistance significantly increased (43.4 %)
in girls who have shown the features of PCOS. Weight gain observed in 69 (50.7 % - Obese)
and 40(29.4%- very obese) of girls respectively. Different types of menstrual irregularities such
as oligomenorrhea 50(36.8%), secondary amenorrhea 28 (20.6%) primary amenorrhea 5
(3.7%) were observed. 53(39.0%) adolescent girls had normal cycle but evidence of PCO on
ultrasound. Infertility was found in 32 (23.5%) of participant followed by hirsutism& acne in 59
(43.4%) 45 (33.1%) of woman respectively. Conclusions: There is significant association of
PCOS with hyperinsulinemia. Hyperinsulinemia if persist can lead to metabolic syndrome with
its serious sequelae .Steps should be taken for early recognition of PCOS in young woman