POLYCYSTIC OVARIAN SYNDROME;

DETERMINATION OF ALTERATIONS IN GLUCOSE LEVEL AND LIPID PROFILE

Abstract

Objective: The objective of the present study was to determine the changes in the glucose level and lipid profile in patients with
polycystic ovarian syndrome (PCOS). Study Design: Descriptive study. Place and Duration of the study: This study was conducted at
Institute of Molecular Biology and Biotechnology, The University of Lahore from June 2009 to June 2010. Patients and Methods: Total 50
patients with PCOS were included and 50 age-matched control subjects were also selected for comparison. Their glucose levels and lipid
profile were assessed using commercial kits. The data thus obtained was subjected to statistical analysis. Results: Significant differences
(P<0.05) in fasting blood glucose level and individual parameters of lipid profile were observed in women with PCOS. A higher prevalence of
hypertriglyceridemia, hypercholesterolemia, higher LDL, lower HDL and higher fasting blood glucose levels was explored in PCOS women
than controls. Conclusions: Abnormal glucose level and lipid profile in PCOS women showed that these women are at an increased risk of
developing diabetes and subsequently cardiovascular diseases.