SPONTANEOUS BACTERIAL PERITONITIS

COMPARISON OF TREATMENT WITH CIPROFLOXACIN AND CEFTRIAXONE IN PATIENTS WITH CIRRHOSIS LIVER AND ASCITES

Abstract

Objective: To compare the efficacy of ciprofloxacin with ceftriaxone in the treatment of spontaneous bacterial peritonitis in
patients with cirrhosis liver and ascites. Design: This hospital based quasi-experimental study. Setting: Department of Medicine, Khyber
Teaching Hospital Peshawar. Period: October, 2009 to April, 2010. Material and Methods: A total of 200 patients were selected by nonprobability
purposive sampling method after obtaining an informed consent. Sample size was calculated through WHO statistical calculator. All
the selected patients had clinical and biochemical evidence of cirrhosis liver and spontaneous bacterial peritonitis. Both sexes were included in
the study. They were randomly divided into two groups; group I was treated with ciprofloxacin and group II was treated with ceftriaxone.
Results: 200 patients including 124 males and 76 females with spontaneous bacterial peritonitis were included in the study. 100 patients each
were treated with ciprofloxacin and ceftriaxone in the two groups. 82% responded favourably to 5 days course of I/V 200mg ciprofloxacin and
91% were cured with 5 days therapy of I/V 2gm ceftriaxone. Conclusions: Both ceftriaxone and ciprofloxacin are equally effective in the
treatment of spontaneous bacterial peritonitis.