ACETAMINOPHEN

REVERSAL OF ACETAMINOPHEN INDUCED NEPHROTOXIC PHENOTYPE IN MALE WISTAR RATS WITH PHOENIX DACTYLIFERA L

Abstract

Introduction: Nephrotoxicity is an important side effect of many medicine and chemotherapeutic agents. Active ingredients from natural sources have shown promising results to alleviate these side effects. Objectives: We aimed to investigate the effects of aqueous Date fruit extract in animal model of paracetamol induced nephrotoxicity in rats. Study Design: Experimental. Setting: Sargodha Institute of Health Sciences Sargodha. Period: January 2017-September 2017. Material & Methods: 30 rats were randomly divided into five groups treatment groups. Treatments were given daily for two weeks. Control group (Group I) is the treatment naïve one. Paracetamol (2 g/kg body weight/day) was given to group 2. Group 3 received extract of date fruit prepared in water (600 mg per kg body weight per day) for one week before paracetamol (2g per kg body weight per day) in the next week. Animals of group 4 were given paracetamol for a duration of 7 days and were then administered the extract of date palm in water. 5th group was given paracetamol (2 g per kg per day) and 600 mg extract of date fruit in water solution per kg body weight at the same time. Results: Renal function was recorded to be significantly altered by paracetamol toxicity and these effects were effectively reversed by the date fruit extract. Conclusion: The acetaminophen induced nephrotoxic changes were reversed by ductylifera in rats.