PORTAL GASTROPATHY

CHARACTERISTIC HISTOLOGICAL FEATURES OF PORTAL GASTROPATHY IN LIVER CIRRHOSIS AND ITS CORRELATION WITH CHILD-PUGH SCORE.

Abstract

Objectives: To study the characteristic histological features of Portal gastropathy and its correlation with Child-Pugh Score in liver cirrhosis patients. Study Design: Cross sectional study. Place and Duration: Department of Anatomy and Gastroenterology Unit, Isra University Hospital from June to December 2012. Subjects and Methods: Gastric biopsies from 85 cases of liver cirrhosis with portal gastropathy were collected by non probability
convenient sampling. Olympus XQ 140 (version 3) was used for 2 mm thick tissue specimens by punch biopsy. Tissue pieces were preserved in 10% formalin. 3-5 μ thick tissue specimens were stained with H & E for microscopic examination. Results: Portal Gastropathy was noted in 91.7% of total study subjects. Gastric glands showed increase counts and increased size noted in 60.12% and 57.65% of cases respectively. Pyloric antrum revealed inflammatory cell infiltration of lamina propria. 95.2% inflammatory cells comprised of lymphocytes. Capillary congestion and edema was noted in 9.4% of cases. Spearman correlation showed positive correlation of Portal gastropathy and Child Pugh Class (CPC) score (R2=0.5244, p=0.0001).
Conclusion: Portal Gastropathy was noted in 91.7%. Histological showed increase in size, length and count of gastric glands, capillary congestion and inflammatory cell infiltration. Spearman correlation showed positive correlation of Portal gastropathy and Child Pugh Class (CPC) score (R2=0.5244, p=0.0001).