CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM

Abstract

Objective: The study was conducted to determine the frequency of Chloroquine-resistant Plasmodium falciparum. Subjects
& Methods: This was a descriptive case series study conducted at Muhammad Medical College Mirpurkhas & Liaquat University Hospital
Hyderabad/ Jamshoro, from January 2007 to December 2007. Total 160 patients with acute attack of fever were selected & studied who fulfilled
the inclusion criteria. The WHO extended test was done by giving 25 mg/kg body weight of Chloroquine base over 3 days. The interpretation
of the test was done as per criteria laid down by WHO. Results: Out of one hundred sixty, 110 (68.75%) were males and 50 (31.25%) were
females with ratio of 2.2:1. The age range 16-45 years with mean 28±12 years. Seventy one patients (44.375%) were Chloroquine sensitive.
Chloroquine-resistance (CQR) Rl, Rll & both Rl Rll noted were 28.125%, 15.645% & 43.75% respectively. The CQR- R III was not observed
in our study. Conclusions: In view of this situation, more organized and thorough studies must be conducted to elucidate the epidemiology,
geographic-distribution & degree of Chloroquine resistance. And the local strategies be made to overcome this problem and to assess the need
for changing the first line drug.