LOW DOSE HEPARIN;

THERAPEUTIC BENEFIT IN POSTPARTUM CEREBRAL VENOUS THROMBOSIS

Abstract

Objective: To evaluate the therapeutic benefit of low dose heparin in cerebral venous thrombosis, occurring during period of
perpeurum. Study design: Descriptive study. Setting: Department of Medicine DHQ Hospital Mirpur (Department of Obs/Gynae DHQ Hospital
Mirpur(AK). Period: January 2010 to November 2011. Method: This study was carried on 100 patients with history of postpartum cerebral
venous thrombosis. Out of which 48 on heparin and 52 formed the control group. The ages of all patients were between 20 to 30 years.
Parameter recorded included history. Blood pressure.,the diagnosis was supported by cranial computed tomography. The secondary causes
were ruled out on the basis of history and physical examination. The data and results were analyzed in SPSS. Results: Out of 48 patients in
heparin group 30 with non-heamorrhage lesion and 18 with haemorrhagic infarction). 52 in control group. 34 non-haemorriagic lesion and 18
with haemorragic infarct .in non-haemorrhagic CVT, there is no death in heparin group as compared to 5 deaths in control group. In patients with
haemorriagic lesions, there were 5 deaths in heparin group as compared to 7 deaths in the control group. Heparin faed better than the control
group, both in patients with haemorrhagic as well as non-haemorrhagic lesions. Conclusions: Low molecular weight (LMWH) at low doses is
safe and effective for both non-haemorrhage and haemorrhgic infarct of postpartum cvt with regard to recovery and outcome as compared to
control group.