SERUM LIPID PROFILE

SIGNIFICANCE OF RISK FACTORS REGARDING OFFSPRINGS OF PREMATURE CORONARY HEART DISEASE PATIENTS

Abstract

… Objectives: This study was conducted to determine serum lipid profile in children
of premature coronary heart disease patients and compare results between children having
parents with one, two or three risk factors. Study Design: A cross sectional comparative study.
Patients and Methods: Ninety seven (97) subjects having parents with one risk factor, sixty three
(63) subjects having parents with two risk factors and sixty five (65) subjects having parents with
three risk factors were selected from Punjab Institute of Cardiology Lahore. Fifty (50) age and sex
matched subjects of parents without a history of coronary heart disease were also selected. The
serum total cholesterol, serum triglycerides, serum low density lipoprotein cholesterol and
serum high density lipoprotein cholesterol was performed and results were compared. Results:
Offsprings of parents having more number of risk factors had statistically significantly high total
cholesterol and low density lipoprotein cholesterol as compared with offsprings of parents
having one risk factor. Triglycerides and high density lipoprotein cholesterol of offsprings of
parents having one, two, three or more than three risk factors were comparable. Offsprings of
parents having premature coronary heart disease (CHD) had abnormal lipid levels as compared
with control group. Conclusions: Coronary heart disease risk factors are significant regarding
abnormal lipid levels. Offsprings of premature CHD patients are prone to develop CHD as
compared to normal control group. Genetic predisposition seems to be important in
development of CHD.