CANCER TYPES;

CORRELATION OF RENAL AND LIVER FUNCTION TESTS

Abstract

Introduction: This study attempts to highlight the relation of various types of
cancers to abnormalities in liver and renal function tests. Objectives: Correlation of deranged
renal and liver function tests to different types of cancers in industrial workers who are exposed to
industrial chemicals and carcinogens. Patients and Methods: This non-interventional study
included 100 hundred confirmed cases of cancer were selected and studied from July 2011 to
December 2011. The study was conducted at Fatima Memorial Hospital/College of Medicine &
Dentistry, Lahore . Results: Out of these 100 patients, 21 had CA lung, 19 had lymphoma, 14 had
sarcoma, 13 had CA breast, 6 had CA prostate, 4 had CA liver, 3 had CA colon, 3 had CA ovary, 3
had CA testis, 2 had leukemia, 2 had multiple myeloma, 2 had CA gall bladder, 2 had CA stomach,
1 had CA esophagus, 1had CA tongue, 1had CA parotid, 1 had CA rectum, 1 had CA cervix and 1
had CA larynx. Among lymphoma, non-Hodgkin lymphoma was more than Hodgkin lymphoma
(out of 19 patients, 13 had non-Hodgkin and 6 had Hodgkin lymphoma). Out of 14 patients of
sarcomas, 5 had Ewing sarcoma, 4 had chondrosarcoma, 3 had fibrosarcoma and 2 had
liposarcoma. Similarly the serum bilirubin levels in liver cancer, ovarian cancer, multiple
myeloma, stomach and gall bladder cancer were 1.50±0.31, 1.17±0.10, 1.46±0.15 and
1.40±0.50 mg% were 32.38±18.81, 37.73±4.35, 34.43±4.35, 45.00±46.17, 31.33±44.70,
65.25±31.14, 33.67±80.90, 99.00±73.08, 50.00±98.49, 33.50±75.0, 36.50±85.0 and
49.0±11.0 μ/l respectively which were statistically significantly higher (p<0.05) then control
individuals. respectively which were significantly higher (p<0.05) than the control individuals
Similarly the ALT levels in lung cancer, lymphoma, sarcoma, breast cancer , prostate cancer, liver
cancer, leukemia, ovarian cancer, cancer of colon, multiple myeloma, cancer of testis and
stomach. The mean serum creatinine levels in lung cancer, liver cancer and cancer of colon were
0.89±0.05, 0.90±0.16 mg% respectively which were significantly higher than the control
individuals (p<0.05). Conclusions: The renal and liver function tests should be frequently
monitored in cancer patients from industrial back grounds.