NONULCER DYSPEPSIA

FREQUENCY IN YOUNG PATIENTS AND ITS RESPONSE TO HELICOBACTER PYLORI ERADICATION AND TRIAL OF PROTON PUMP INHIBITORS

Abstract

Objectives: To determine the frequency of nonulcer dyspepsia in patients
presenting with the peptic ulcer like symptoms and to determine the effect of H. pylori eradication
on dyspeptic symptoms and the effect of six weeks trial of proton pump inhibitor as treatment
measure. Study design: Cross-sectional study. Setting: Combined Military hospital Quetta,
Department of medicine. Period: Six months from Oct, till March 2009. Subjects and Methods:
Patients coming to medicine department with complaints of dyspepsia. Results: Total no of
patients were 145 out of which male were 90 while 55 were females. The mean age was 29.68
+ 4.53. These subjects were given H pylori eradication therapy and response was graded as
patients responded or no response. 89 subjects (61.4%) responded to H pylori eradication
treatment while 56 subjects (38.6%) showed no symptomatic benefit. Non responder to
eradication i.e., 37 males and 36 females were given further six week treatment with omeprazole,
and subjective response to treatment was graded as complete resolution found in 31 patients (
21.4% ), while partial resolution was present in 15 patients (10.3%). 07 patients (4.8%) showed
no improvement while 03 patients (2.1%) showed worsening of symptoms. Conclusions: The
prevalence of non-ulcer dyspepsia is high among symptomatic individuals. The response to
H pylori eradication was significant. Non responders also showed considerable symptomatic
benefit with PPI. Therefore, individuals with recurrent dyspeptic symptoms should be given trial
of H. pylori eradication.