SPECTRUM OF PANCYTOPENIA

A TERTIARY CARE EXPERIENCE

Abstract

Pancytopenia refers to a reduction in all the three cellular elements of blood.
Pancytopenia is a common but important hematological problem encountered in routine
clinical Practice. It may be a presenting feature of many underlying serious and life threatening
illnesses. Objective: Present study was planned to appraise various clinico- etiological
factors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: Hematology
Department of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period:
July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients with
Pancytopenia were included in the study. Complete blood count, bone marrow aspirations and
trephine biopsies were performed after clinical history and physical exam. Data were analyzed
by using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bone
marrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiological
factors with male predominance. Fever and pallor were striking presenting clinical features.
Conclusion: We conclude that Pancytopenia is a common problem with an exhaustive list
of differential diagnosis, some of which are easily treatable and reversible. Therefore early
detection with optimal diagnostic approach to Pancytopenia is required for better management
of patients.