H.PYLORI INFECTION

FREQUENCY IN CIRRHOTIC PATIENTS WITH UPPER G.I BLEED

Abstract

Objectives: To study the frequency of H. pylori infection and its association as a
cause of upper G.I bleeding in cirrhosis. Study Design: Cross Sectional Study. Setting: Medical
Unit III, JPMC Karachi. Period: January 2014 to December 2014. Methods: 100 patients of
established cirrhosis with upper G.I bleeding were included in this study. These patients were
evaluated for viral etiology of cirrhosis. An upper G.I Endoscopy was performed in all patients
and antral biopsies were taken. Rapid urease test was performed on biopsy specimen for
detection of H.pylori infection. Results: Out of 100 patients 71 were males and 29 were females
with age ranging between 14 to 70 years. Among them 53% patients turned out to be positive
for H.Pylori infection with rapid urease test. H.pylori infection was detected in 68.7% of HBsAg
positive patients and in 50% of Anti HCV positive patients. On upper G.I endoscopy 96 patients
had PHG and among them 50 (52%) were positive for H.pylori. 4 patients did not have PHG
and among them 3 (75%) were positive for H.pylori. Gastric ulcer was present in 17 patients
and amongst them H.pylori was detected in 10 (58.8%) cases. Duodenal ulcer was present in 5
patients and among them 2 (40%) were positive for H.pylori. Gastritis was present in 17 cases
among them 11 (64%) were positive for H.pylori. Duodenitis was present in 13 cases among
them 11 (84.6%) patients were positive for H.pylori infection. Conclusion: The frequency of
H.pylori infection was low in cirrhotic patients. No association was seen in H.pylori infection
and causes of upper G.I bleeding in cirrhosis including PHG, gastric ulcer and duodenal ulcer