LIVER CIRRHOSIS

HCV AND HBV INFECTION WITH A COMPARATIVE STUDY TO ASSESS THE POOR PROGNOSTIC FACTORS AND IN-HOSPITAL MORTALITY RATE

Abstract

Objectives: The aim behind this study was to scientifically assess the poor
prognostic factors and in-hospital mortality rate in patients infected with HCV and HBV infection
with liver cirrhosis. Study Design: Comparative hospital based study. Setting: Gastroenterology
and hepatology dedicated center, Asian Institute of Medical Sciences (AIMS), Hyderabad.
Period: Thirty one months from 1st October 2012 to 31st May 2015. Patients and Methods: 419
participants between the ages of 20 to 80 years including both male and female and diagnosed
either with HCV or HBV infection along with cirrhosis were included. Data were entered and
analyzed by using Statistical Package for the Social Sciences version 20.0. Results: Out of total
419 patients, the mean age and S.D. of HBV patients were 41.21 ± 11.77 and HCV patients
were 50.44 ± 10.07 years. The overall mortality rate was 11.69% (N = 49) among them patients
with of HBV infection had a comparatively higher mortality rate than patients with HCV infection,
13.07% and 11.07%, respectively. The most common risk factors observed in our study were
Hepatorenal syndrome (41.17%) in HCV cirrhotics and hematemesis (34.37%) in HCV cirrhotic
patients. Conclusion: Our study shows that overall mortality is greater in HBV cirrhotic patients
than with HCV cirrhotics. Poor in-hospital mortality factors vary in both HBV and HCV related
cirrhotic patients and this discrepancy in the observation is universally observed