SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)

PATIENTS WITH LIVER CIRRHOSIS

Abstract

Systemic inflammatory response syndrome (SIRS) is a generalized disorder,
immune response to infection which results in disturbed microcirculation, visceral perfusion and
ultimately visceral failure. Objectives: To determine the frequency of systemic inflammatory
response syndrome in patients with liver cirrhosis. Design: Cross sectional descriptive.
Period: Six months study. Setting: At Liaquat University Hospital Hyderabad. Patients and
methods: All the patients with liver cirrhosis for 06 months duration admitted in the ward were
further evaluated for systemic inflammatory response syndrome. The data was analyzed in
SPSS 16 and the frequency and percentage was calculated. Results: During six months study
period, total 100 cirrhotic subjects were studied for SIRS. The mean ± SD for age in all (100)
cirrhotic patients was 45.74 ± 7.537. The mean temperatures was 40.42±0.32 where as it was
39.72±0.43 and 38.92±0.11 in male and female population respectively. The mean heart beat
was 128.42±6.74 where as it was 115.83±8.93 and 120.62±5.53 in male and female population
respectively. The mean respiratory rate was 25.31±3.52 where as it was 23.52±2.31 and
26.63±3.21 in male and female population respectively. The mean white blood cell count was
28.81±4.51 where as it was 23.74±4.73 and 30.83±5.73 respectively. The SIRS was observed
in 70% subjects of which 47(67.1%) were males and 23(32.9%) were females (p=0.04). Majority
of SIRS subjects were 30-39 years of age and male population was predominant (p=0.03). The
gender distribution in relation to severity of liver disease was statistically significant (p=0.05)
while the SIRS in relation statical analysis. Conclusions: The systemic inflammatory response
syndrome occurs in patients with liver cirrhosis.