KELOIDS AND HYPERTROPHIC SCARS;

COMPARISON OF INTRALEISIONAL INJECTION OF TRIAMCINOLONE ALONE AND TRIAMCINOLONE MIXED WITH 5 FLOUROURACIL IN TREATMENT OF KELOIDS AND HYPERTROPHIC SCARS.

Abstract

Objectives: To compare the effectiveness of triamcinolone alone and
triamcinolone mixed with 5-flourouracil used for intralesional injection to treat symptomatic
hypertrophic scars and keloids. Study Design: Prospective study. Place & duration of study:
Departments of Plastic and General Surgery, Khawaja Muhammad Safdar Medical College,
Sialkot from January 2014 to September 2016. Material and Methods: Plastic and general
surgery outpatients with symptomatic keloids and hypertrophic scars fulfilling inclusion criteria
were registered. Adult patients irrespective of gender, areas involved and size of the keloids
were included. Patients refusing treatment, pregnant and lactating women were excluded;
similarly the patients not completing the follow up for at least 3 months were dropped from the
statistical analysis. Patients’ response to treatment was judged by the reduction in the physical
size of keloids and subjective improvement in symptoms of itching, discomfort, pain, deformity
or redness. Minimum of three sessions of treatment was must for assessment of outcome.
Data was entered and analysis done by SPSS v 22. Results: Of the 293 outpatients 115 were
treated by the mixed triamcinolone and 5 flourouracil while 178 patients were injected with
triamcinolone only. Female patients were more in number with ratio of 2.8:1. Good response
to treatment with Triamcinolone alone was obtained in 69 (38.76%) while good response was
seen in 62 (53.91%) of patients with intralesional Triamcinolone mixed with 5-flourouracil.
Conclusion: The intra-lesional steroid injection commonly used as its treatment has convincing
response. The presently used mixture of steroids and 5-flourouracil has more promising results
as regards patients’ improvement in symptomatology as well as physical reduction in the size.