TERMINALIA CHEBULA RETZ;
SPASMOGENIC AND SPASMOLYTIC PROPERTIES
DOI:
https://doi.org/10.29309/TPMJ/2013.20.05.1203Keywords:
Spasmogenic,, Spasmolytic,, Small intestine,, T. chebula.Abstract
Objective: To study the spasmogenic and spasmolytic properties of Terminalia chebula. Diagnostic parameter of smooth
muscle activity was used for the determination of characteristic spasmogenic and spasmolytic activity of T. chebula. Design:
Experimental study. Setting: This experimental study was carried out at the Department of Pharmacology, Faculty of Pharmacy, Karachi
University. Period: From 2005 to 2006. Material & method: This experimental study was conducted on isolated smooth muscle of
rabbit's intestine. Segment of small intestine (jejunum and ileum) was mounted in Tyroid's solution filled organ bath with maintained
o temperature at 37 C to record dose response activity. Results: It is observed that at the dose of 1 mg/ml there is a slight decrease in the
response (0.88 cm 0.035 cm) as compare to control (1.15cm 0.040 cm). At 10 mg/ml there is a relaxing response of smooth muscle
activity (0.85cm 0.08cm) from control (1.08cm 0.125cm). While the relaxation is prominent at the doses of 20 mg/ml (0.9cm 0.5cm)
and 25 mg/ml (0.55cm 0.035cm) from control (1.4cm 0.155cm) and (1.3cm 0.07cm) respectively with (p value 0.05). The effect of
-2 ethyl acetate fraction shows initially relaxation and this effect disappeared after the administration of acetylcholine 1x10 M, but full
response of acetylcholine is not produced due to occupancy of muscarinic receptor by the extract. Conclusions: The effect of T. chebula
showed a spontaneous decrease in the movement of smooth muscles of rabbit's intestine as compared to control experiments.
