EFFECT OF PROPRANOLOL;
RIFAMPICIN INDUCED HEPATOTOXICITY IN RABBIT’S LIVER
DOI:
https://doi.org/10.29309/TPMJ/2017.24.06.1194Keywords:
Hepatotoxicity,, antitubercular therapy,, micrometric analysis,, scanning electron microscopy,, hepatic cords,, hepatocytes.Abstract
Tuberculosis is the disease required long term treatment. Rifampicin is the major
element of antiTB therapy if resistance is not documented. Potential of antitubercular dugs
to produced hepatoxicity is very high and among all antiTB agents rifampicin (RIF) induced
hepatoxicity stands on top. Rifampicin is the major element of antiTB therapy if resistance is not
documented. But its hepatotoxic effects are the main hurdle to continue with this therapy. In this
study RIF were administered to the rabbit alone or in combination of propranolol to evaluate the
hepatotoxic effects of RIF and reduction of hepatotoxicity by propranolol. Histological evaluation
of liver tissue on higher magnification, its micrometric analysis and SEM (scanning electron
microscopy) of liver were used to estimate the effects of this combination. Micrometry revealed
that number of viable hepatocytes, their diameter and nuclear diameter were altered. SEM
micrograph showed distorted and swollen hepatic cords. All of these changes successfully
turned to normal by combined administration of propranolol. Propranolol successfully improves
the hepatic architecture proved by both qualitative and quantitative microscopy.
