FRACTURES

CAUSES OF LOW VITAMIN D AND EFFECTS OF 25(OH) SUPPLEMENTATION IN PATIENTS ABOVE 50 YEARS

Authors

  • Nasir Zulfiqar Karachi.
  • Hamid Mahmood Continental Medical College Lahore.
  • Ghazia Irfan PM&DC, Islamabad
  • Ammara Waqar PIQC, Lahore.
  • Nadeem Iqbal PIQC, Lahore.

DOI:

https://doi.org/10.29309/TPMJ/2015.22.07.1193

Keywords:

25-hydroxyvitamin D levels, vitamin D deficiency, low-energy fracture

Abstract

To find out the effect in increase in serum 25(OH) vitamin D levels after
supplementation with 1000 IU/day of vitamin D in patients with low vitamin D levels and other
factors which may affect the increase in vitamin D levels. Study Design: Retrospective study.
Period: January 2013 and June 2014. Setting: Ch. Rehmat Ali Trust Teaching Hospital in the
Lahore. Methods: The study included patients > 50 years with a low-energy fracture and a
vitamin D level < 25 nmol/l. Results: 85 patients were included, mean basal 25(OH) vitamin D
level was 22 nmol/l. After a mean of 10 weeks, the mean increase in vitamin D was 49.5 nmol/l.
Only 45.1% reached the target level of > 50 nmol/l. The increase was correlated with the basal
level of vitamin D (p < 0.05), and the time interval between the two vitamin D measurements
(p < 0.05) and was inversely related to body weight (p < 0.05), but was not related to age,
gender or renal function. Conclusions: We found that the generally recommended dosage of
1000 IU of vitamin D per day resulted in suboptimal serum levels after ten weeks of treatment in
more than half of the patients. The increase in vitamin D levels was higher in patients with low
body weight and in patients with very low basal vitamin D levels. These data suggest that these
patients should initially be treated with higher dosages of vitamin D. If not possible, vitamin D
measurements should be performed after at least six months of supplementation with dosage
adjustment.

Author Biographies

Nasir Zulfiqar, Karachi.

Associate Professor 0f Surgery,
Sir Syed institute of Medical Sciences

Hamid Mahmood, Continental Medical College Lahore.

Professor of Bio Chemistry

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Published

2015-07-10