ALCOHOLIC LIVER DISEASE (ALD)

IMPLICATION OF OXIDATIVE STRESS & EXTRAPOLATIVE FACTORS IN PATIENTS SUFFERING, UPDATE FROM LOCAL POPULATION OF PUNJAB-PAKISTAN

Abstract

Objective: The aim of the present study was to investigate the changes in
biochemical parameters including lipid profile, liver and kidney profile as well as oxidative stress
profile, particularly in patients suffering from alcoholic liver disease (ALD). Study design: Fifty
chronic alcoholics admitted for treatment to the in-patient wards at Jinnah Hospital, Lahore-
Pakistan. Chronic alcoholics with alcohol abuse for more than four to five years, and with or
without clinical complications, were included. Apparently twenty healthy individuals served
as control. Period: 2012-2013. Materials and methods: Various circulating biochemical
biomarkers including renal profile, hepatic and lipid profile were evaluated. Moreover, stress
markers (MDA. SOD, GSH and catalase) were also investigated. Results: A very strong direct
and indirect correlation of ALP was found with TB, MDA and GSH (r=.950**, r=.929** and r=-
.967** respectively, P<0.01). MDA was observed having very strong indirect correlation with
GSH and catalase (r=-.909** and r=-.777** respectively, P<0.01). Conclusion: All parameters
in combinations may be useful indicator or may be good and reliable biochemical markers for
identification and determination of severity of alcoholic liver diseases (ALD). The damaging
of hepatocytes due to the consumption of alcohol disturbs almost all types of biochemical
coordination in the biological system.