DYSLIPIDIMIA

TO DETERMINE THE VARIOUS LIPID PROFILE PATTERN IN PATIENTS OF CHRONIC RENAL FAILURE

Abstract

Objective: To determine the various lipid profile pattern of dyslipidimia in patients
of chronic renal failure. Study design: Cross-sectional study. Place and duration of study:
This study was conducted at Nephrology department of Isra University hospital Hyderabad
and Medicine Department Civil hospital Nawabshah, from October 2013 to September 2014.
Methodology: This study consisted of 237 patients of chronic renal failure asses on detailed
history regarding chronic renal failure, patients were subject to relevant investigations i.e.
fasting lipid profile and venous blood was drawn after 14 hours fasting state in the early morning
and sent to laboratory for analysis of fasting lipid profile. Inclusion Criteria were all patients of
chronic renal failure with 1years history, age > 35 to 60 years and either any sex. Diagnosed on
the basis of serum creatinine as define in operational definition. Exclusion Criteria were patients
on lipid lowering agents, acute complication of diabetes mellitus such as diabetic keto-acidosis,
patients suffering from hypothyroidism, type 1 DM and HTN, lactic-acidosis, hypoglycemia.
Results were prepared with help of tables and graphs. Data was analyzed through SPSS software.
Results: Out of 237 patients, 113(47.68%) patients were 51 to 60 years of age, 94(39.66%) were
41 to 50 years of age and 30(12.66%) were 35 to 40 years as presented in Chart No 1. The
average age of the patients was 50.11±6.94 years. There were 54.43% (129/237) male and
45.57% (108/237) female. Various lipid profile pattern of dyslipidimia in patients of chronic renal
failure are presented in table-I. Results of fasting lipid profile are Triglycerides high in 86(36.3%),
HDL low in 76(32.1%) cases, LDL in high 83(35%) cases, Cholesterol high in 105(44.3%) cases
and VLDL-cholesterol high in 68(28.7%). Stratification analysis showed that lipid profile pattern
of dyslipidemia was insignificant between male and female as presented in table 2. While with
respect to age groups, rate of Cholesterol, triglycerides, LDL-cholesterol was high in above
40 years of age groups as compare to 30 to 40 years of age groups. Rate of low HDL was
also high in above 40 years of age groups as compare to 30 to 40 years as presented in table
3. Conclusions: In conclusion, our study demonstrated that dyslipidemia often our patients
chronic renal failure. This underscores the need for the first test patients with lipid abnormalities
early treatment can prevent cardiovascular events delay chronic kidney disease.