SPINAL ANAESTHESIA

COMPARISON BETWEEN PROPHYLACTIC LOW DOSE KETAMINE AND ONDANSETRON FOR PREVENTION OF SHIVERING DURING SPINAL ANAESTHESIA IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES

Abstract

Perioperative shivering is a common problem during spinal anaesthesia. It
causes tremendous deleterious effects on metabolism of body. Despite of re-warming and
raising the ambient temperature, several drugs are under research to evaluate their preventive
role in shivering during anaesthesia like tramadol, butorphanol, midazolam, ketamine and
ondansetron. The present study was conducted to evaluate the effect of prophylactic low dose
ketamine and ondansetron for prevention of shivering during spinal anaesthesia. Objective:
To compare prophylactic low dose ketamine with ondansetron for prevention of shivering
during spinal anaesthesia in patients undergoing lower abdominal surgeries. Study Design:
Randomized controlled trial. Setting: Department of Anaesthesia, Nishtar Hospital Multan.
Period: November 2012 to May 2013. Material and methods: A total of 256 patients were
included in the study divided into two equal groups. Results: In this study basic demographics
like age, gender, mean weight and height and type of surgery patients underwent were
similar, having no significant difference in both groups, while on comparison in both groups,
the frequency of shivering revealed 4.69%(n=6) in K Group and 11.72%(n=15) in O Group
while remaining 95.31%(n=122) in K and 88.28%(n=113) in O Group had no findings of the
morbidity, p value was calculated as 0.03, which showed significant difference. Conclusion:
The result of the study concluded that prophylactic intravenous administration of low dose
ketamine (0.25mg/kg) is significantly more effective than ondansteron (4 mg) for prevention of
shivering during spinal anesthesia in patients undergoing lower abdominal surgeries.