INDUCING ABORTION IN 2ND TRIMESTER;

EFFICACY OF MISOPROSTOL WITH PREVIOUS ONE CESAREAN SECTION

Abstract

Objectives: To determine the efficacy of misoprostol for inducing the abortion
in 2nd trimester with previous one cesarean section. Study Design: Descriptive case series.
Place and Duration of Study: Department of Obstetrics & Gynaecology, Nishtar Medical
College and Hospital Multan from May, 2015 to October 2015. Material and Methods: The
sample included 139 patients having pervious one cesarean section with gestational age 14-20
wks assessed on ultrasound and having an indication for termination of pregnancy like IUD,
fetal anomalies (neural anomaly, cardiac anomaly), medical disorder hypertension, diabetes
mellitus. General physical examination was done by the researcher. Investigations including
complete blood count, complete urine examination, random blood sugar, liver and kidney
function tests, coagulation profile were carried out. The researcher placed misoprostol 200μg
per vaginally every 4 hourly with overnight rest maximum for 72 hours. Efficacy of misoprostol
was judged in terms of success rate in achieving termination. Termination of pregnancy was
considered successfully if cervical os progressively dilated and both fetus and placenta expelled
within 72 hours after insertion of 1st dose of misoprostol without surgical intervention. Results.
A total of 139 cases fulfilling the inclusion criteria were enrolled to determine the efficacy of
misoprostol for inducing abortion in 2nd trimester with previous one cesarean section. Among
these patients 84.89% (n=118) were treated effectively, 15.11% (n=21) were not effectively
treated. Conclusion: Misoprostol for inducing the abortion in 2nd trimester with previous one
cesarean section is effective for expulsion of the fetus and placenta.