THYROID MALIGNANCY IN MULTI NODULAR GOITER;

INCIDENCE, A RETROSPECTIVE STUDY IN SOUTHERN PUNJAB.

Abstract

Objectives: To assess the incidence of malignancy in patients with Multinodular goiter in southern Punjab. Study design:
A retrospective study. Place & Duration of study: Department of General Surgery, Sheikh Zayed Medical College & Hospital Rahim Yar
Khan, from April 2010 to May 2012. Patients and Methods: All patients were presented in OPD with history of Multinodular goiter on
clinical examination or USG neck. FNAC of any dominant nodule or suspicious nodule on USG neck was performed. All patients were
operated & total thyroidectomies were done in all patients irrespective of the age. We sent all specimens for histopathological examination
and reports were collected from department. The whole information collected was entered in a pre designed proforma. Results: During 2
years period, total 141 patients of thyroid disease were seen in OPD out of which 98 patients have Multinodular goiter. Histopathology of
these patients showed 10 malignancies & 88 benign. Most of the patients that turned out to be malignant belong to 41-50 years age
group. 7 patients were female and 3 were male. Among the malignancies 50% were papillary, 30% were follicular, and 10% were
anaplastic carcinoma & lymphomas each. Conclusions: Multinodular goiter (MNG) is the commonest indication of thyroidectomy in
iodine deficient areas of Pakistan. This study concludes that don’t consider MNG as a benign disease anymore until proved otherwise.