A comparative study of intrathecal 1mg nalbuphine as adjunct to 15mg of bupivacaine 0.75% versus 15mg of bupivacaine 0.75% alone in spinal anesthesia for infraumbilical surgeries.

Abstract

Objective: To compare mean duration of analgesia when 1mg Nalbuphine is added to 15mg of Bupivacaine 0.75% versus 15mg of Bupivacaine 0.75% alone in spinal anesthesia for infraumbilical surgeries. Study Design: Randomized Controlled Trial. Setting: Department of Anesthesia, Allied Hospital, Faisalabad. Periods: April 2024 to October 2024. Methods: Total 60 subjects undergoing elective infraumbilical surgery under spinal anesthesia were assigned to two groups; Group A received inj. 0.75% Bupivacaine 15mg along with inj. Nalbuphine 1mg (0.1ml) in subarachnoid space via 25 gauge Quinke type spinal needle and Group B received 0.75% bupivacaine 15mg alone in subarachnoid space using 25guage spinal needle. Analgesia duration (hours) was calculated from sensory block onset to first request of analgesia using VAS score. Analysis of data was done using SPSS.23, for statistical significance p-value ≤0.05 was taken. Results: Sensory and motor block onset in Group A vs B noted was 3.25 ± 0.41 minutes & 6.36 ± 0.66 minutes vs 4.31 ± 0.39 minutes & 7.90 ± 0.63 minutes (p<0.001). Duration of postoperative analgesia was longer in Group A 5.77 ± 0.57 hours vs 5.03 ± 0.29 hours in Group B (p < 0.001). Conclusion: These findings suggest that intrathecal Nalbuphine added to Bupivacaine can considerably prolonged the duration of analgesia versus when Bupivacaine used alone in spinal anesthesia for infraumbilical surgeries irrespective of age, gender, or comorbidity status.