PRE-ECLAMPSIA

LEPTIN IN PRE-ECLAMPSIA IN THIRD TRIMESTER OF PREGNANCY A HOSPITAL BASED TRIAL

Authors

  • Anwar Khan Nowshera Medical College
  • Hamzullah Khan Department of Hematology Nowshera Medical College

DOI:

https://doi.org/10.29309/TPMJ/2016.23.02.868

Abstract

Objectives: To determine the relation of leptin, hypertension and body mass
index with pre-eclampsia in the 3rd trimester of pregnancy in a hospital based study. Design:
descriptive observational study. Setting: three teaching hospital of Peshawar, Khyber teaching
hospital, Hayatabad medical complex and lady reading hospital Peshawar. Duration: June
2012-dec 2012. Inclusion criteria: all women in their third trimester without any co-morbidity.
Exclusion criteria: were all diabetic and first and 2nd trimester pregnant ladies. Procedure:
relevant information on height, weight, body mass index (BMI), pulse, blood pressure and leptin
were recorded on a predesigned questionnaire prepared in accordance with the objectives
of the study. Data was analyzed in MS-Excel. Results: A total of 80 pregnant ladies included.
Majority of the patients were in the age range of 17-26 years of age. Maximum number 30(37.5%)
of patients were in weight ranging 66-75 kg. We observed maximum number of patients were
normotensive systolic BP 110-130mmHg (47%). About 43% of patients had BP>140mmHg up
to 200mmHg. 6% had Diasatolic BP between 130-140mmHg. 23.5% had BMI>32.6. 38% had
BMI between 27.62-32.62. We observed that majority of the patients were in the leptin serum
range of 229.57-329.57. 7.75% had serum leptin level above 329 with a maximum of 829.6
in one patient at top in data. Conclusion: Serum leptin level in pregnancy increases in third
trimester with a determined relation of serum leptin level with gestaional hypertension and preeclampsia.

Author Biographies

Anwar Khan, Nowshera Medical College

Assistant Professor,
Department of Physiology

Hamzullah Khan, Department of Hematology Nowshera Medical College

Assistant Professor,

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Published

2016-02-10