SHEAR WAVE ELASTOGRAPHY

ASSESSMENT OF LIVER FIBROSIS IN A PATIENT OF CHRONIC LIVER DISEASE ASSOCIATED INFECTED BY HEPATITIS B AND C

Authors

  • Kausar Saldera Jinnah Postgraduate Medical Centre (JPMC), Karachi.
  • Nargis Fatima Naqvi Address: A-382, Block –I, North Nazimabad, Karachi 3. Professor and Head
  • Tariq Mahmood Jinnah Postgraduate Medical Centre (JPMC) Karachi.
  • Shazia Sarwar Shaikh Jinnah Postgraduate Medical Centre (JPMC) Karachi

DOI:

https://doi.org/10.29309/TPMJ/2016.23.01.806

Keywords:

Shear Wave Elastography, Metavir score, Hepatitis, Fibrosis

Abstract

Objectives: Assessment of liver fibrosis by shear wave elastography in a patient
of chronic liver disease associated infected by hepatitis B and C. Study Design: Observational
Study. Place and Duration of Study: This study was conducted in the Department of
Radiology JPMC Karachi from January to September 2015. Methodology: All the diagnosed
cases of Chronic liver disease aged between 30 to 60 years and both gender associated with
hepatitis B and C were selected. Patients using lipid-lowering drugs were excluded from this
study. Assessment of liver fibrosis dividing into two groups, 1st group patients suffering liver
disease since 2 years and 2nd group more than 2 years on SWE Qualitative and Quantitative
analysis was done and staging of fibrosis according to METAVIR SCORE was done. Shear
wave elastography and scoring are F0-F1 (5.3-7.1), F>2 (7.5-8.5) Grade 1-Mild, F>3 (9.5-13)
Grade 2- Moderate and F>4 (13.1-18.8) Grade 3-Severe. Results: Out of the 80 patients, the
majority was found to be male. 44(55%) males and 36(45%) females. Ratio between the male
and female is 1.2:1. Mean age was found to be 44.57+7.54 years. Mostly Grade 2- Moderate
changes observed in liver were 15(18.75%) of Hepatitis B Surface Antigen positive patients while
14(17.5%) Hepatitis C Virus Antibodies positive patients. Followed by Grade 1-Mild changes
were 12(15%) of Hepatitis B+ve patients and 7(8.75%) Hepatitis C+ve positive patients.
Grade 3-Severe were 9(11.25%) of Hepatitis B+ve patients and 4(5%) Hepatitis C+ve positive
(Table No 2). 4(5%) cases observed mild changes in both positive. Conclusion: Elastography
techniques is noninvasive method can provide clinicians with innovative options as potential
alternatives to liver biopsy for improving the quality of care for those patients with liver diseases.

Author Biographies

Kausar Saldera, Jinnah Postgraduate Medical Centre (JPMC), Karachi.

Medical Office
Radiology Department

Nargis Fatima Naqvi, Address: A-382, Block –I, North Nazimabad, Karachi 3. Professor and Head

M. Phil Student

Tariq Mahmood, Jinnah Postgraduate Medical Centre (JPMC) Karachi.

Professor and Head of Radiology
Department

Shazia Sarwar Shaikh, Jinnah Postgraduate Medical Centre (JPMC) Karachi

Medical Office
Radiology Department

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Published

2016-01-10