DEEP VENOUS THROMBOSIS

MEAN PLATELET VOLUME, D-DIMER AND DOPPLER SONOGRAPHY. PATIENTS OF SURGICAL WARDS OF LIAQUAT UNIVERSITY HOSPITAL

Abstract

Objectives: To study mean platelet volume (MPV) in deep venous thrombosis
(DVT) as evaluated by D-Dimmer and Doppler sonography. Study Design: Case control study.
Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences
Jamshoro/Hyderabad from May 2013 to April 2014. Subjects and Methods: A sample
of 106 subjects; 50 controls and 53 diagnosed patients of DVT were studied. DVT patients
were included according to inclusion and exclusion criteria and after results of Sonography
and D-Dimer were available. The Blood samples were collected in bottles containing sodium
citrate as anticoagulant. MPV was generated by Sysmex KX 21 hematology analyzer. Informed
consent was sought from the volunteer subjects. The Data was analyzed using SPSS version
21.0. Statistically significance was defined at p-value of ≤0.05. Results: Mean platelet
volume was elevated in deep venous thrombosis patients which were confirmed by clinical
examination, sonography and D-Dimer. MPV was elevated in cases; 10.0±0.7fl compared to
controls; 9.55±0.63fl (p=0.001). D-Dimmer was elevated in deep venous thrombosis patients
(p=0.0001). Age, gender and platelet counts did not revealed any significant differences
between cases and controls (p>0.0.05). Conclusion: The present study reports elevated
MPV in patients suffering from deep venous thrombosis and it is concluded that MPV may be
considered as a risk factor for DVT