ADVERSE EFFECTS OF NON-BRANDED SOFT DRINK

ADVERSE EFFECTS OF NON-BRANDED SOFT DRINK ON THE RENAL HISTOLOGY - AN EXPERIMENTAL STUDY IN AN ALBINO RAT MODEL

Authors

  • Sajjad Ali Almani Isra University, Hyderabad.
  • Shoukat Ali Memon Isra University, Hyderabad.
  • Aftab Ahmed Shaikh Al-Tibri Medical College Isra University Karachi Campus.

DOI:

https://doi.org/10.29309/TPMJ/18.4365

Keywords:

Soft Drink, Adverse Effects, Kidney Histology, Rats

Abstract

Objectives: Investigating the Adverse effects of non-branded soft drink on the
renal histology in an albino rat model. Study Design: Experimental study. Place and Duration:
Department of Anatomy, Isra University, in collaboration with Animal House, Department of
Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tando Jam over six
months duration 2014. Methodology: A sample of 30 adult Wistar albino rats of was selected
according to criteria. Animals were randomly divided into 3 groups. Group A (n=10) control
rats, Group B (n=10) control rats given normal diet (12 hours fasting) and Group C (n=10)
experimental rats. 3- 5 μ thick renal tissue sections were prepared, stained with H & E and
examined by light microscopy. Data was analyzed on statistical software SPSS 21.0 ver
(IBM, incorporation, USA) at 95% (α)-level significance was taken at P-value ≤ 0.05. Results:
Experimental group C showed an increase in kidney size and weight observed even after 12
hours of fasting (P=0.0001). Histological examination of experimental kidneys show gaping
Bowman`s capsules, interstitial edema, glomerular distortion, calcifications, acidophilic
hyalinization of renal tubules, vacuolization of epithelial cell, pyknotic nuclei and necrosis.
Epithelial cells revealed fragmentation and sloughing in experimental rat kidney. Conclusion:
The present study reports deleterious adverse effects of non-branded soft drink on the renal
histology in an experimental albino rat model.

Author Biographies

Sajjad Ali Almani, Isra University, Hyderabad.

MBBS, M.Phil.
Assistant Professor
Department of Anatomy

Shoukat Ali Memon, Isra University, Hyderabad.

MBBS, M.Phil.
Assistant Professor
Department of Anatomy

Aftab Ahmed Shaikh, Al-Tibri Medical College Isra University Karachi Campus.

MBBS, M.Phil.
Associate Professor
Department of Pharmacology

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Published

2018-11-10