CHILDHOOD BRONCHIAL ASTHMA

SERUM CHOLECALCIFEROL IN CHILDHOOD BRONCHIAL ASTHMA AND ITS ASSOCIATION WITH ASTHMA SEVERITY

Authors

  • Nathumal Maheshwari Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.
  • Omperkash Khemani Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.
  • Siri chand Hamdard Medical College Karachi.
  • Bilawal Hingorjo Dow University of Health Sciences/ Civil Hospital Karachi Sindh, Pakistan.
  • Mehmood Shaikh Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.
  • Anjum Rehman Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

DOI:

https://doi.org/10.29309/TPMJ/18.4352

Keywords:

Cholecalciferol, Childhood Asthma, Serum Ig E, Eosinophils

Abstract

Objectives: Determine serum cholecalciferol in childhood bronchial asthma and
its association with asthma severity. Study Design: Cross sectional study. Place and Duration:
Department of Paediatrics, Layari General Hospital, Shaheed Muhtrama Benazir Bhutto Medical
College Karachi from January 2015 – November 2016. Subjects and Methods: 100 diagnosed
cases of childhood bronchial asthma and 100 controls were included. 5 ml venous blood was
used for the full blood counts and sera were used for the serum cholecalciferol and IgE. Data
was analysed on statistical software (SPSS v 22.0, IBM, Incorporation, USA) at 95% confidence
interval (P ≤ 0.05). Results: Mean ± SD age of controls and cases was noted 8.23±1.84 and
9.40 ±0.54 years. Low serum cholecalciferol was noted in the cases compared to the controls
(25.7±14.5 vs. 38.3±15.5 ng/dl) (p=0.0001) with a rise in blood eosinophil, absolute eosinophil
counts and serum Ig E. Serum cholecalciferol shows negative correlation with serum IgE, blood
eosinophil and absolute eosinophil counts. Conclusion: The present study reports low serum
cholecalciferol in childhood bronchial asthma. Cholecalciferol shows negative association with
severity of asthma.

Author Biographies

Nathumal Maheshwari, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS
Assistant Professor Paediatrics

Omperkash Khemani, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS
Assistant Professor Paediatrics

Siri chand, Hamdard Medical College Karachi.

MBBS, MCPS, FCPS
Assistant Professor Paediatrics

Bilawal Hingorjo, Dow University of Health Sciences/ Civil Hospital Karachi Sindh, Pakistan.

MBBS, FCPS
Assistant Professor Pediatrics

Mehmood Shaikh, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS (Paediatrics),
FCPS (Neonatology)
Assistant Professor Paediatrics

Anjum Rehman, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS
Principal
Head of Department
Gynecology and Obstetrics

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Published

2018-11-10